Current Grants

National Cancer Center 2021/2022 Grants

The following post-doc fellowship grants and renewals were approved for 2021/2022

Gretchen M Alicea, Ph.D.

Johns Hopkins Univ, Baltimore MD

PROJECT: Dissecting the role of lipid metabolism in metastasis and immune therapy efficacy in older melanoma patients

$40,000

Chiwei Xu, Ph.D.

The Rockefeller Univ, New York, NY

PROJECT: Crosstalk between epithelial stem cells and peripheral nerves in cancer

$40,000

Elena Grossi, Ph.D.

Icahn School of Medicine, New York, NY

PROJECT: Profiling SWI/SNF complex mutations in melanoma initiation
$40,000

Carmen Adriaens, Ph.D.

Massachusetts General Hospital, Boston, MA

PROJECT: Targeting DMNT1 to induce anti-cancer gene expression programs and synthetic lethality

$40,000

Narek Darabedian, Ph.D.

Dana-Farber Cancer Institute, Boston, MA

PROJECT: Covalent manipulation of undrugged metabolic proteins to treat cancer

$40,000

Robin Armstrong, Ph.D.

Memorial Sloan Kettering, New York, NY

PROJECT: Determining differential roles for p53 loss-of-function and R270H mutants during leukemia development
$40,000

Varadha B Venkadakrishnan, Ph.D.

Dana-Farber Cancer Institute, Boston, MA

PROJECT: Collaboration between EZH2 and DNA methyltransferase to drive lineage programming in advanced prostate cancer

$40,000

Manqi Zhang, Ph.D.

Duke University, Durham, NC

PROJECT: Loss of ALK4 promotes EMT through regulation of Golgi-mediated receptor glycosylation in pancreatic cancer

“Loss of ALK4 function via mutation of loss of expression is a frequent event in pancreatic cancer and associated with poor clinical outcomes. The NCC grant allows me to study the mechanism by which loss of ALK4 function contributes to cancer progression and metastasis.”

$42,000

Ibtehaj Naqvi, M.D., Ph.D.

Duke University, Durham, NC

PROJECT: Mitigating inflammation using nucleic acid scavengers to prevent breast cancer metastasis

“I am studying how chronic inflammation promotes breast cancer metastasis and I am using a novel polymer-based approach to block this chronic inflammation and prevent breast cancer metastasis.”

$42,000

Sohini Chakraborty, Ph.D.

New York Univ School of Medicine, New York, NY

PROJECT: Therapeutic targeting of stem cells in pediatric acute myeloid leukemia

“I am studying how the cell surface protein CD97 promotes stem cell function in pediatric acute myeloid leukemia, and if it may be therapeutically targeted with antibodies.”

$42,000

Mireia Perez Verdaguer, Ph.D.

University of Pittsburgh School of Medicine

PROJECT: Improving the Tumor-Suppressing Efficacy of EGFR Antibodies on Head-and-Neck Squamous Cell Carcinoma

“Despite the well-established role of EGFR in tumorigenesis, Cetuximab, a therapeutic EGFR antibody, helps only a small fraction of patients. This project aims to understand whether inhibition of stress-induced signaling processes may increase accessibility of EGFR to Cetuximab and improve its antitumoral effectiveness.”

$42,000

David M. Gau, Ph.D.

University of Pittsburgh School of Medicine

PROJECT: Profilin-1 as a Target for Vascular Normalization and Treatment for Renal Cell Carcinoma
“A common theme of clear cell renal cell carcinoma, the most common subtype of kidney cancer, is the highly vascularized nature of the tumor environment. Anti-angiogenic treatments for this type of cancer typically will see cancer progression due to innate resistant mechanisms. I was interested in this project due to my previous PhD work on identifying fundamental targets to regulate blood vessel formation, that is, targeting processes that have limited alternative mechanisms.”
$42,000

Giulia Cova, Ph.D.

New York University Medical Center, New York, NY

PROJECT: Defining the mechanisms by which genetic alterations in CTCF and CTCFL drive oncogenic transcription programs
“DNA is packaged within the nucleus in a highly organized manner which is important for gene regulation. Appropriate DNA folding relies on the architectural protein CTCF that is frequently genetically altered in cancer.  The goal of my project is to understand how these lesions contribute to oncogenic programs.”
$42,000

David Frankhouser, Ph.D.

Beckman Research Institute of the City of Hope, Duarte California

PROJECT: Detecting neovascularity in MRI to identify and predict breast cancer 

“I am excited to develop analytical and machine learning methods to identify vessels to extend early detection of biologically aggressive breast cancers”

$42,000

James J. Kaminski, Ph.D.

Boston Children’s Hospital

PROJECT: Identification of immunological circuits that regulate cGvHD

“I am working to identify the mechanisms that drive chronic graft-vs-host disease, the most deadly long-term complication for bone marrow transplants patients.”

$42,000

William Maguire, M.D., Ph.D.

University of Pittsburgh

PROJECT: Biomarkers of sulforaphane for therapeutic prevention of melanoma
“My research interests comprise early phase drug development in the field of therapeutic prevention of melanoma.  The lack of systemic agents to prevent melanoma represents an important unmet need, given that the incidence of melanoma in the United States continues to rise more rapidly than that of most other common cancers.”
$42,000