About Aggressive Cancer Research

Aggressive Cancer Research

The National Cancer Center created the Aggressive Cancer Research project in 2015 to provide additional funding for this important and pressing area of cancer research.

Our Icahn School of Medicine at Mt. Sinai funding grant provides research whose goal is the development of strategies aimed at blunting the very essence of cancer. This in turn can lead to the improvement of current therapies for highly aggressive cancers whose chemotherapeutic regimens often result in high toxicity for patients, treatments that are difficult for patients to tolerate.

Aggressive Cancer Research

Current Grants and Renewals

National Cancer Center has been proud to award grants to many fine research organizations. We know that a cure lies in research and we are committed to supporting as many research projects as we can.

Narek Darabedian, Ph.D.

Dana-Farber Cancer Institute, Boston, MA

PROJECT: Covalent manipulation of undrugged metabolic proteins to treat cancer


Manqi Zhang, Ph.D.

Duke University, Durham, NC

PROJECT: Loss of ALK4 promotes EMT through regulation of Golgi-mediated receptor glycosylation in pancreatic cancer


William Maguire, M.D., Ph.D.

Univ of Pittsburgh, Pittsburgh, PA

PROJECT: Biomarkers of sulforaphane for therapeutic prevention of melanoma


Past Beneficiaries

Siva Karthik Varanasi, PhD.

Salk Inst for Biological Studies

PROJECT: Evaluating the role of bile acids as a metabolic checkpoint of anti-tumor T cell Hepatocellular Carcinoma


Yuanyuan Xie, Ph.D.

Regents of the Univ of Colorado

PROJECT: Elucidating the functional and genomic impact of retrocopies on cancer


Manoela Tiago dos Santos, Ph.D.

Thomas Jefferson University, Philadelphia, PA

PROJECT: BET inhibition to optimize BRAFi/MEKi therapy for mutant BRAF

Zhentao Yang, PhD.

UCLA Division of Dermatology

PROJECT: Immune evasion mechanisms during MAPK inhibitor therapy in melanoma

Jin Qian, M.D., PhD.

UCLA Division of Dermatology

PROJECT: Immune evasion mechanisms during MAPK inhibitor therapy in melanoma

Nishana Mayilaadumveettil, Ph.D.

NYU School of Medicine

PROJECT:Role of CTCF Mutations in Altering Nuclear Architecture and Gene Regulation in Cancer

Gabriele Varano, Ph.D.

Icahn School of Medicine at Mt Sinai, NY

PROJECT: Cellular determinants of genetic heterogeneity during MYC-driven B cell lymphomagenesis

Elaine Bich Than, Ph.D.

Weill Medical College of Cornell University, NY

PROJECT: The role of the microbiome and butyrate in CpG Island Methylator Phenotype colorectal cancer


2021 New and Renewed Research Grants


2021 Grants


Total Grand Funding To Date

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2021/2022 Post-doc Fellowship
Grants and Renewals