Aggressive Cancer Research

Aggressive Cancer Research

The National Cancer Center created the Aggressive Cancer Research project in 2015 to provide additional funding for this important and pressing area of cancer research.

Our Icahn School of Medicine at Mt. Sinai funding grant provides research whose goal is the development of strategies aimed at blunting the very essence of cancer. This in turn can lead to the improvement of current therapies for highly aggressive cancers whose chemotherapeutic regimens often result in high toxicity for patients, treatments that are difficult for patients to tolerate.

Aggressive Cancer Research

Current Grants and Renewals

National Cancer Center has been proud to award grants to many fine research organizations. We know that a cure lies in research and we are committed to supporting as many research projects as we can.

Sydney Moyer, Ph.D.

Dana-Farber Cancer Institute, Boston MA

PROJECT: Th1 cells with increased adhesion pathway expression are required for inflammation-associated colorectal cancer development and progression


Lizhong Ding, Ph.D.

The University of California, Los Angeles

PROJECT: Liver specific fibrosis drives immunosuppression in metastatic melanoma


Audifas Salvador Matus Meza, Ph.D.

Univ of Nebraska Medical Center, Omaha, NE

PROJECT: Development of an NTSR1-targeted Radiotherapeutic for Colorectal Cancer and Other NTSR1-positive Cancers


Past Beneficiaries

William Maguire, M.D., Ph.D.

Univ of Pittsburgh, Pittsburgh, PA

PROJECT: Biomarkers of sulforaphane for therapeutic prevention of melanoma


Chiwei Xu, Ph.D.

The Rockefeller Univ, New York, NY

PROJECT: Crosstalk between epithelial stem cells and peripheral nerves in cancer


Manqi Zhang, Ph.D.

Duke University, Durham, NC

PROJECT: Loss of ALK4 promotes EMT through regulation of Golgi-mediated receptor glycosylation in pancreatic cancer


Yuanyuan Xie, Ph.D.

Regents of the Univ of Colorado

PROJECT: Elucidating the functional and genomic impact of retrocopies on cancer


Siva Karthik Varanasi, PhD.

Salk Inst for Biological Studies

PROJECT: Evaluating the role of bile acids as a metabolic checkpoint of anti-tumor T cell Hepatocellular Carcinoma


Manoela Tiago dos Santos, Ph.D.

Thomas Jefferson University, Philadelphia, PA

PROJECT: BET inhibition to optimize BRAFi/MEKi therapy for mutant BRAF

Zhentao Yang, PhD.

UCLA Division of Dermatology

PROJECT: Immune evasion mechanisms during MAPK inhibitor therapy in melanoma

Jin Qian, M.D., PhD.

UCLA Division of Dermatology

PROJECT: Immune evasion mechanisms during MAPK inhibitor therapy in melanoma

Nishana Mayilaadumveettil, Ph.D.

NYU School of Medicine

PROJECT:Role of CTCF Mutations in Altering Nuclear Architecture and Gene Regulation in Cancer

Gabriele Varano, Ph.D.

Icahn School of Medicine at Mt Sinai, NY

PROJECT: Cellular determinants of genetic heterogeneity during MYC-driven B cell lymphomagenesis

Elaine Bich Than, Ph.D.

Weill Medical College of Cornell University, NY

PROJECT: The role of the microbiome and butyrate in CpG Island Methylator Phenotype colorectal cancer


2023 New and Renewed Research Grants


2023 Grants


Total Grand Funding To Date