Aggressive Cancer Research
The National Cancer Center created the Aggressive Cancer Research project in 2015 to provide additional funding for this important and pressing area of cancer research.
Our Icahn School of Medicine at Mt. Sinai funding grant provides research whose goal is the development of strategies aimed at blunting the very essence of cancer. This in turn can lead to the improvement of current therapies for highly aggressive cancers whose chemotherapeutic regimens often result in high toxicity for patients, treatments that are difficult for patients to tolerate.
Current Grants and Renewals
National Cancer Center has been proud to award grants to many fine research organizations.
We know that a cure lies in research and we are committed to supporting as many research projects as we can.
Sydney Moyer, Ph.D.
Dana-Farber Cancer Institute, Boston MA
PROJECT: Th1 cells with increased adhesion pathway expression are required for inflammation-associated colorectal cancer development and progression
TYPE: NEW GRANT
Lizhong Ding, Ph.D.
The University of California, Los Angeles
PROJECT: Liver specific fibrosis drives immunosuppression in metastatic melanoma
TYPE: RENEWAL
Audifas Salvador Matus Meza, Ph.D.
Univ of Nebraska Medical Center, Omaha, NE
PROJECT: Development of an NTSR1-targeted Radiotherapeutic for Colorectal Cancer and Other NTSR1-positive Cancers
TYPE: RENEWAL
Past Beneficiaries
Siva Karthik Varanasi, PhD.
Salk Inst for Biological Studies
PROJECT: Evaluating the role of bile acids as a metabolic checkpoint of anti-tumor T cell Hepatocellular Carcinoma
2019-2021
Manqi Zhang, Ph.D.
Duke University, Durham, NC
PROJECT: Loss of ALK4 promotes EMT through regulation of Golgi-mediated receptor glycosylation in pancreatic cancer
2021-2022
Nishana Mayilaadumveettil, Ph.D.
NYU School of Medicine
PROJECT: Role of CTCF Mutations in Altering Nuclear Architecture and Gene Regulation in Cancer
2017-2018
William Maguire, M.D., Ph.D.
Univ of Pittsburgh, Pittsburgh, PA
PROJECT: Biomarkers of sulforaphane for therapeutic prevention of melanoma
2021-2022
Chiwei Xu, Ph.D.
The Rockefeller Univ, New York, NY
PROJECT: Crosstalk between epithelial stem cells and peripheral nerves in cancer
2021-2022
Yuanyuan Xie, Ph.D.
Regents of the Univ of Colorado
PROJECT: Elucidating the functional and genomic impact of retrocopies on cancer
2019-2021
Manoela Tiago dos Santos, Ph.D.
Thomas Jefferson University, Philadelphia, PA
PROJECT: BET inhibition to optimize BRAFi/MEKi therapy for mutant BRAF
2019-2020
Zhentao Yang, PhD.
UCLA Division of Dermatology
PROJECT: Immune evasion mechanisms during MAPK inhibitor therapy in melanoma
2018
Jin Qian, M.D., PhD.
UCLA Division of Dermatology
PROJECT: Immune evasion mechanisms during MAPK inhibitor therapy in melanoma
2017
Gabriele Varano, Ph.D.
Icahn School of Medicine at Mt Sinai, NY
PROJECT: Cellular determinants of genetic heterogeneity during MYC-driven B cell lymphomagenesis
2016-2017
Elaine Bich Than, Ph.D.
Weill Medical College of Cornell University, NY
PROJECT: The role of the microbiome and butyrate in CpG Island Methylator Phenotype colorectal cancer
2015
